Dr. Klement started her career as a veterinarian. After immigrating to Canada she re-trained, and entered the field of medicine. She received her MD in 1992 from McMaster University in Hamilton, Ontario, and went on to train in Pediatrics at the Hospital for Sick Children, University of Toronto in Toronto, Canada. She finished her Fellowship in Pediatric Hematology/Oncology at the Hospital for Sick Children, University of Toronto in 1997.At a time when few clinical oncologists entertained the thought of tumor angiogenesis becoming a target for anti-tumor therapy, she decided to focus her research on developing novel antiangiogenic treatments. She received the prestigious National Cancer Institute of Canada Terry Fox Postgraduate Research Fellowship in 1997 to do this work, and joined the laboratory of a prominent scientist, Dr. Robert Kerbel, at the Sunnybrook & Women's College Health Sciences Center, University of Toronto. Her post–doctoral work led to the first publication on metronomic chemotherapy, and caused a paradigm shift in our thinking about anti-cancer therapy. Metronomic chemotherapy continues to be explored in numerous clinical trials, and forms the basis of introduction of most new antiangiogenic agents.

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